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郭传龙

作者:    信息来源:    发布时间: 2019-07-11

化工学院教师介绍:郭传龙

个人简介

工作职位:药物制剂教研室,讲师

办公地址:青岛科技大学四方校区精细化工楼105室(青岛市市北区郑州路53号)

工作邮箱:gcl_cpu@126.comguochuanlong@qust.edu.cn

2019年获中国科学院海洋研究所海洋生物学专业博士学位,20136月至20166月,任职于山东省眼科研究所。20197至今,任职于青岛科技大学化工学院药物制剂教研室。主要从事新型抗肿瘤药物研制与开发、活性化合物筛选及作用机制研究。作为项目负责人,主持山东省自然科学基金1项,参与国家自然科学基金项目3项。近五年,发表SCI论文20余篇,其中第一作者发表SCI论文12篇,作为主要参与人授权国家发明专利4项。

个人荣誉与获奖

1、荣誉称号

2019年中国科学院大学优秀毕业生。

2、科研获奖

2018-2019年中国科学院大学博士研究生国家奖学金。

教学情况

体内药物分析:32课时,研究生,约15人。

论文、专著与专利

1、主要论文

[1] Chuanlong Guo1, Lijun Wang1, Xiuxue Li, Shuaiyu Wang, Xuemin Yu, Kuo Xu, Yue Zhao, Jiao Luo, Xiangqian Li, Bo Jiang, Dayong Shi. Discovery of novel bromophenol – thiosemicarbazone hybrids as potent selectve inhibitors of poly(ADPribose) polymerase-1 (PARP-1) for use in cancer. Journal of Medicinal Chemistry. 2019, 62, 3051−3067. (IF: 6.045)

[2] Lijun Wang1, Chuanlong Guo1, Xiuxue Li, Xuemin Yu, Xiangqian Li, Kuo Xu, Bo Jiang, Xiaoling Jia, Chao Li, Dayong Shi. Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment. European Journal of Medicinal Chemistry. 2019, 177:153-170. (IF:4.833)

[3] Chuan-Long Guo1 Li-Jun Wang1, Yue Zhao, Hua Liu, Xiang-Qian LiBo Jiang, Jiao Luo, Shu-Ju Guo, Ning Wu, Da-Yong Shi. A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway. Mar. Drugs. 2018, 16, 43. (IF: 3.772)

[4] Kuo Xu1, Chuanlong Guo1, Jie Meng, Haiying Tian, Shuju Guo, Dayong Shi. Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents Through ROS-mediated Apoptotic Pathway. Mar. Drugs. 2019, 17, 207.(IF: 3.772)

[5] Li-Jun Wang1, Chuan-Long Guo1, Xiang-Qian Li, Shuai-Yu Wang, Bo Jiang, Yue Zhao, Jiao Luo, Kuo Xu, Hua Liu, Shu-Ju Guo, Ning Wu, Da-Yong Shi. Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation. Mar. Drugs. 2017, 15, 34. (IF: 4.379)

[6] Chuanlong Guo1, Mengshuang Li1, Xia Qi, Guiming Lin, Fenghua Cui, Fengjie Li, Xianggen Wu. Intranasal delivery of nanomicelle curcumin promotes corneal epithelial wound healing in streptozotocin-induced diabetic mice. Sci Rep. 2016, 6: 29753. (IF: 4.259)

[7] Chuanlong Guo, Fenghua Cui, Mengshuang Li, Fengjie Li, Xianggen Wu. Enhanced corneal permeation of coumarin-6 using nanoliposomes containing dipotassium glycyrrhizinate: in vitro mechanism and in vivo permeation evaluation. RSC Adv. 2015, 5, 75636. (IF: 3.289)

[8] Chuanlong Guo1, Yan Zhang1, Zhao Yang, Mengshuang Li, Fengjie Li, Fenghua Cui, Ting Liu, Weiyun Shi, Xianggen Wu. Nanomicelle formulation for topical delivery of cyclosporine A into the cornea: in vitro mechanism and in vivo permeation evaluation. Sci Rep. 2015, 5: 12968. (IF: 5.228)

[9] Yue Zhao1, Chuanlong Guo1, Lijun Wang, Shuaiyu Wang, Xiangqian Li, Bo Jiang, Ning Wu, Shuju Guo, Renshuai Zhang, Kun Liu, Dayong Shi. A novel fluorinated thiosemicarbazone derivative- 2-(3,4-difluorobenzylidene) hydrazinecarbothioamide induces apoptosis in human A549 lung cancer cells via ROS-mediated mitochondriadependent pathway. Biochemical and Biophysical Research Communications. 2017, 491:65-71. (IF: 2.559)

[10] Hua Liu1, Chuanlong Guo1, Shuju Guo, Lijun Wang, Dayong Shi. Design and Synthesis of a Fluorescent Probe with a Large Stokes Shift for Detecting Thiophenols and Its Application in Water Samples and Living Cells. Molecules. 2019, 24, 375. (IF: 3.098)

[11] Guo Chuanlong1, Wang Lijun1, Jiang Bo, Shi Dayonng. Bromophenol curcumin analog BCA-5 exerts an antiangiogenic effect through the HIF-1α/VEGF/Akt signaling pathway in human umbilical vein endothelial cells. Anti-Cancer Drugs. 2018, 29(10):965-974. (IF: 1.869)

[12] Chuanlong Guo1, Lijun Wang1, Yue Zhao, Bo Jiang, Jiao Luo, Dayong Shi. BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway. Experimental and Therapeutic Medicine. 2019, 17: 3848-3858. (IF: 1.410)

2、授权专利

[1] 吴祥根,郭传龙,李梦双,史伟云。 一种33G针头注射用雷珠单抗眼玻璃体腔内缓释药物. 2019,中国,授权专利号: ZL 201510371614.5

[2] 吴祥根,郭传龙,李梦双,史伟云。 一种姜黄素胶束滴眼液及其制备方法. 2018,中国,授权专利号: ZL 201510389806.9

[3] 吴祥根,郭传龙,李梦双,史伟云。 一种姜黄素胶束鼻腔给药用溶液及其制备方法. 2017,中国,授权专利号: ZL 201510391874.9

[4] 史大永,王li军,郭传龙,江波,王帅玉,赵越。一类新型溴酚氨基硫脲类化合物及其制备和药物与用途。2019,中国,授权专利号: ZL 201611069927.6

承担的科研项目

[1] 2015.7-2016.12姜黄素纳米胶束经鼻腔粘膜-三叉神经节-角膜神经通路治疗糖尿病性角膜病变及其机制研究。山东省自然科学基金,项目编号:ZR2015PH06。主持,已结题。

[2] 2016.1-2018.12增溶型环孢素A滴眼液的临床前开发研究。山东省科技攻关计划。结题,项目参与人。

[3] 2016.1-2018.12糖尿病引起血视网膜内屏障ABC转运蛋白表达/功能改变的机制及其作为干预靶点防治糖尿病视网膜病变的研究。国家自然科学基金青年基金。在研,项目参与人。

[4] 2018.1-2021.12 基于分子杂合和多样性导向合成策略构建新型海洋溴酚杂合体库及靶向eIF4E抗肿瘤活性研究。国家自然科学基金面上项目。在研,项目参与人。