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吴祥根
发布时间:2017-05-19    作者:      审核人:    点击:[]

化工学院教师介绍:吴祥根

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个人简介

工作职位:药物制剂教研室教授,博士/硕士生导师,主管药师,临床药师(卫生部抗感染药物专业)

办公地址:青岛科技大学四方校区CCF1019室(青岛市市北区郑州路53号)

工作邮箱:wuxianggen@126.comxwu@qust.edu.cn

2002年获华中科技大学药学专业学士学位,2007年获华中科技大学药理学专业医学博士学位,20076月至20166月,任职于山东省眼科研究所/青岛眼科医院,20116月晋升副研究员,20166至今,任职于青岛科技大学化工学院药物制剂教研室。主要从事眼科创新药物与治疗等领域研究。作为项目负责人,主持国家自然科学基金项目3项、山东省重点研发计划等省部级科研项目7项和市厅级科研项目3项,与企业合作产学研项目5项。参与获得国家科技进二等奖1项(9/10)、山东省科技进步一等奖2项(6/12,10/10)、山东省优秀创新团队1项。发表SCI学术论文40余篇,获授权国家发明专利12

个人荣誉与获奖

1、科研成果获奖

[1] 2016,山东省科技进步奖,一等奖(6/12),角膜病诊治的关键技术及临床应用

[2] 2012,山东省优秀创新团队核心成员

[3] 2011,国家科技进步奖,二等奖(9/10),感染性角膜病创新理论及其技术应用

[4] 2009,山东省科技进步奖,一等奖(10/10),真菌性角膜炎的应用基础及临床学研究

教学情况

1、本科生课程

[1]  药事管理学:32课时,本科生,约60人。

2研究生课程

[1]  药学前沿:32课时,研究生,约30人。

论文、专著与专利

1、论文选(近三年)

[1] Qiqi Li, Qilong Cao*, Zhixin Yuan, Meiqi Wang, Peng Chen, Xianggen Wu*. A novel self-nanomicellizing system of empagliflozin for oral treatment of acute pancreatitis: an experimental study[J]. Nanomedicine, 2022 Feb 9:102534.

[2] Yaru Li, Lei Zhou, Mengmeng Zhang, Runzhi Li, Guohu Di, Hongyun Liu*, Xianggen Wu*. Micelles based on polyvinylpyrrolidone VA64: A potential nanoplatform for the ocular delivery of apocynin[J]. Int J Pharm, 2022, 615: 121451

[3] Qiqi Li, Meng Xin, Xianggen Wu*, Bo Lei*. Novel nano-phytochemical ophthalmic solution for marked improvement of corneal wound healing via the inhibition of HMGB1 signaling in healthy and diabetic mice[J]. Nanomedicine (London), 2022, 17(3): 151-165

[4] Qiqi Li, Xianggen Wu*, Meng Xin*. Strengthened rebamipide ocular nanoformulation to effectively treat corneal alkali burns in mice through the HMGB1 signaling pathway[J]. Exp Eye Res, 2021, 213: 108824.

[5] Hui Yang, Qilong Cao, Zhixin Yuan, Xianggen Wu*, Mengshuang Li*. Enhanced therapeutic efficacy of a novel self-micellizing nanoformulation loading fisetin against acetaminophen-induced liver injury[J]. Nanomedicine (London), 2021, 16(27): 2431–2448

[6] Qiqi Li, Xiaoming Wu, Shanshan Xin, Xianggen Wu*, Jie Lan*. Preparation and characterization of a naringenin solubilizing glycyrrhizin nanomicelle ophthalmic solution for experimental dry eye disease[J]. Eur J Pharm Sci, 2021, 167: 106020.

[7] Yuzhen Hou, Meng Xin, Qiqi Li, Xianggen Wu*. Glycyrrhizin micelle as a genistein nanocarrier: synergistically promoting corneal epithelial wound healing through blockage of the HMGB1 signaling pathway in diabetic mice[J]. Exp Eye Res, 2021, 204: 108454

[8] Fan Zhang, Dongmei Jia, Qiqi Li, Mengmeng Zhang, Hongyun Liu*, Xianggen Wu*. Preparation and evaluation of a xanthan gum–containing linezolid ophthalmic solution for topical treatment of experimental bacterial keratitis [J]. Pharm Res, 2021, 38(2): 347–359

[9] Yuzhen Hou, Jie Lan, Fan Zhang, Xianggen Wu*. Expression profiles and as potential corneal epithelial wound healing regulation targets of high-mobility group box 1 in diabetic mice[J]. Exp Eye Res, 2021, 202:108364

[10] Fan Zhang, Huabo Chen, Jie Lan, Kaichao Song, Xianggen Wu*. Preparation and in vitro/in vivo evaluations of novel ocular micelle formulations of hesperetin with glycyrrhizin as a nanocarrier [J]. Exp Eye Res, 2021, 202:108313

[11] Xuefei Li, Jingwang Fang, Meng Xin, Qiqi Li, Jun Wang, Hui Yang, Xianggen Wu*. Rebaudioside A/TPGS mixed nanomicelles as promising nanocarriers for nimodipine ocular delivery [J]. Drug Deliv Transl Res, 2021, 11(3), 1119-1132

[12] Kaichao Song, Meixing Yan, Mengshuang Li, Yiwan Geng, Xianggen Wu*. Preparation and in vitro–in vivo evaluation of novel ocular nanomicelle formulation of thymol based on glycyrrhizin [J]. Colloids Surf B Biointerfaces, 2020, 194: 111157

[13] Hui Wang, Yuanlong He, Yuzhen Hou, Yiwan Geng, Xianggen Wu*. Novel self-nanomicellizing formulation based on Rebaudioside A: A potential nanoplatform for oral delivery of naringenin [J]. Materials Science & Engineering C, 2020, 112: 110926

[14] Guigang Li, Lingjuan Xu, Menglin Jiang, Xianggen Wu*. Eye drops and eye gels of levofloxacin: comparison of ocular absorption characterizations and therapeutic effects in the treatment of bacterial keratitis in rabbits [J]. Drug Dev Ind Pharm, 2020, 46(4): 673-681

[15] Fan Zhang, Rong Li, Meixin Yan, Qiqi Li, Yaru Li, Xianggen Wu*. Ultra-small nanocomplexes based on polyvinylpyrrolidone K-17PF: a potential nanoplatform for the ocular delivery of Kaempferol [J]. Eur J Pharm Sci, 2020, 147:105289

[16] Hui Wang, Xuefei Li, Hui Yang, Jun Wang, Qiqi Li, Ruijing Qu, Xianggen Wu*. Nanocomplexes based polyvinylpyrrolidone K-17PF for ocular drug delivery of naringenin [J]. Int J Pharm, 2020, 578:119133

[17] Kaichao Song, Meng Xin, Fan Zhang, Wenjing Xie, Mingyue Sun, Xianggen Wu*. Novel ultrasmall nanomicelles based on rebaudioside A: A potential nanoplatform for the ocular delivery of pterostilbene [J]. Int J Pharm, 2020, 577:119035

学术兼职

学术组织任职

山东省药学会高等药学教育专业委员会委员、山东省药学会儿科药学专业委员会委员、山东省医学会药物临床研究与评价分会青年委员会委员、青岛市药学会药理学专业委员会副主任委员、青岛市药学会临床药学专业委员会委员。

承担的科研项目

纵向项目(近三年)

[1] 2020.1-2022.12,河南省眼科学与视觉科学重点实验室2020年度开放课题,20KFKT001,多靶点调控HMGB1信号通路干预糖尿病性角膜病变的实验研究,项目负责人

[2] 2019.01–2020.12,山东省重点研发计划,2019GSF108027,瑞鲍迪苷A为新型药用辅料及其为载体增溶型环孢素A滴眼液的临床前开发研究,项目负责人。

[3] 2019.01–2020.12,山东省生态化工协同创新中心青年人才基金项目,XTCXQN19,瑞鲍迪苷A为绿色纳米载体增溶型环孢素A滴眼液的研发,项目负责人。

[4] 2018.01–2021.12,国家自然科学基金,81770895,鼻腔黏膜-三叉神经节-角膜神经通路在药物防治糖尿病性角膜病变中的作用及其机制研究,项目负责人。

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