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高巍伟
发布时间:2020-05-13    作者:     点击:[]

个人简介

工作职位:制药工程教研室 讲师

办公地址:青岛科技大学科技园北楼614室

工作邮箱:gww501@qust.edu.cn; gww51@email.swu.edu.cn

2018年6月毕业于西南大学有机化学专业,获理学博士学位。2018年9月-至今,在青岛科技大学化工学院从事科研与教学工作。主要研究方向为:生物有机药物合成、环境药物检测、纳米复合材料的合成与生物应用等领域。发表SCI学术论文20篇,以第一作者或唯一通讯作者在EuropeanJournal of Medicinal Chemistry、SCIENCE CHINA Chemistry、Future Medicinal Chemistry、Biochemical Engineering Journal、Cellulose、Carbohydrate Polymers、Electroanalysis、Journal of The Electrochemical Society、Journal of Materials Science Materials in Electronics等国内外学术期刊发表SCI收录学术论文10篇,其中,ESI高被引论文1篇。申请国家发明专利2项,授权1项。

教学情况

研究生课程

高等有机波谱分析:32课时,硕士生,20人。

本科生课程

药物波谱分析:32课时,本科生,125人。

论文、专著与专利

1主要论文

[1]Wei-Wei Gao, Lavanya Gopala, Rammohan R. Yadav Bheemanaboina, Guo-Biao Zhang, Shuo Li, Cheng-He Zhou. Discovery of 2-aminothiazolyl berberine derivatives as novel effectively antibacterial agents toward clinical drug-resistant Gram-negativeAcinetobacter baumanii. European Journal of Medicinal Chemistry, 2018, 146, 15–37. (ESI高被引, JCR 1区, IF = 5.572)

[2]Wei-Wei Gao, Syed Rasheed, Vijai Kumar Reddy Tangadanchu, Yi Sun, Xin-Mei Peng, Yu Cheng, Feng-Xiu Zhang, Jian-Mei Lin, Cheng-He Zhou. Design, synthesis and biological evaluation of amino organophosphorus imidazoles as a new type of potential antimicrobial agents. SCIENCE CHINA Chemistry, 2017, 60, 769–785. (国内T类,JCR 1区, IF = 6.356)

[3]Wei-Wei Gao, Cheng-He Zhou. Antimicrobial 2-aminothiazolyl quinolones: what is their potential in the clinic? Future Medicinal Chemistry, 2017, 9, 1461–1464. (JCR 2区, IF = 3.607)

[4]Wei-Wei Gao, Feng-Xiu Zhang, Guang-Xian Zhang, Cheng-He Zhou. Key factors affecting the activity and stability of enzymes in ionic liquids and novel applications in biocatalysis. Biochemical Engineering Journal, 2015, 99, 67–84. (JCR 2区, IF = 3.475)

[5]Wei-Wei Gao, Guang-Xian Zhang, Feng-Xiu Zhang. Enhancement of flame retardancy of cotton fabrics by grafting a novel organic phosphorous-based flame retardant. Cellulose, 2015, 22, 2787–2796. (JCR 1区, IF = 4.210)

[6] Feng-Xiu Zhang (硕士导师),Wei-Wei Gao, Ya-Ling Jia, Yi Lu, Guang-Xian Zhang. A concise water-solvent synthesis of highly effective, durable, and eco-friendly flame-retardant coating on cotton fabrics. Carbohydrate Polymers, 2018, 199, 256–265. (JCR 1区, IF = 7.182)

[7] Ya-Mu Xia, Wen Zhang, Meng-Ying Li, Meng Xia, Li-Jia Zou,Wei-Wei Gao*. Effective electrochemical determination of chloramphenicol and florfenicol based on graphene/copper phthalocyanine nanocomposites modified glassy carbon electrode. Journal of The Electrochemical Society, 2019, 166, B654-B663. (JCR 2区, IF = 3.721)

[8] Ya-Mu Xia, Jia-Hong Zhang, Meng Xia, Yan Zhao, Shan-Peng Chu,Wei-Wei Gao*. Peony-like magnetic graphene oxide/Fe3O4/BiOI nanoflower as a novel photocatalyst for enhanced photocatalytic degradation of Rhodamine B and Methylene blue dyes. Journal of Materials Science Materials in Electronics, 2020, 31, 1996-2009. (JCR 3区, IF = 2.220)

[9] Ya-Mu Xia, Meng-Ying Li, Cheng-Long Chen, Meng Xia, Wen Zhang,Wei-Wei Gao*. Employing 3D-rGO-PANI based DNA biosensor as label-free and ultrasensitive “nano-detector” for breast cancer BRCA1 sensing. Electroanalysis, 2020, 32, DOI: 10.1002/elan.202060039.(JCR 3区, IF = 2.544)

[10] Ya-Mu Xia, Shan-Peng Chu, Zi-Yang Liao, Shu-Yu Sun, Xu Cheng,Wei-Wei Gao*. Z-scheme mechanism study of ternary BiPO4/reduced graphene oxide/protonated g-C3N4photocatalyst with interfacial electric field mediating for the effective photocatalytic degradation of tetracycline. Journal of Materials Science Materials in Electronics, 2020, DOI: 10.1007/s10854-020-04050-x (JCR 3区, IF = 2.220)

[11] Shu-Zhen Yang, Zhi-Qiang Dong, Cheng-Cheng Yin, Hui-Juan Yue,Wei-Wei Gao*, Feng-Ke Yang*. Green synthesis of caffeine based on methylating reagent DMC and environmental friendly separating method. Journal of the Chinese Chemical Society, 2020, 1–6. (JCR 4区,IF = 1.554)

[12]Han-Bo Liu,Wei-Wei Gao, Vijai Kumar Reddy Tangadanchu, Cheng-He Zhou, Rong-Xia Geng. Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. European Journal of Medicinal Chemistry, 2018, 143, 66–84. (JCR 1区, IF = 5.572)

[13] Guo-Biao Zhang, Swetha Kameswari Maddili, Vijai Kumar Reddy Tangadanchu, Lavanya Gopala,Wei-Wei Gao, Gui-Xin Cai, Cheng-He Zhou. Discovery of natural berberine-derived nitroimidazoles as potentially multi-targeting agents against drug-resistantEscherichia coli. SCIENCE CHINA Chemistry, 2018, 61, 557–568. (国内T类,JCR 1区, IF = 6.356)

[14] Yu Cheng, Srinivasa Rao Avula,Wei-Wei Gao, Dinesh Addla, Vijai Kumar Reddy Tangadanchu, Ling Zhang, Jian-Mei Lin, Cheng-He Zhou.Multi-targeting exploration of new2-aminothiazolyl quinolones:Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. European Journal of Medicinal Chemistry, 2016, 124, 935–945.(JCR 1区, IF =5.572)

[15]Jie Kang, Lavanya Gopala, Vijai Kumar Reddy Tangadanchu,Wei-Wei Gao, Cheng-He Zhou. Novel naphthalimide nitroimidazoles as multi-targeting antibacterial agents against resistantAcinetobacter baumannii. Future Medicinal Chemistry, 2018. 10, 711–724.(JCR 2区, IF = 3.607)

[16] Jie Kang, Vijai Kumar Reddy Tangadanchu, Lavanya Gopala,Wei-Wei Gao, Yu Cheng, Han-Bo Liu, Rong-Xia Geng, Shuo Li, Cheng-He Zhou. Novel potentially antibacterial naphthalimide-derived metronidazoles: Design, synthesis, biological evaluation and supramolecular interactions with DNA, human serum albumin and topoisomerase II. Chinese Chemical Letters, 2017, 28, 1369–1374. (JCR 2区, IF = 4.632)

[17] Ya-Nan Wang, Rammohan R. Yadav Bheemanaboina,Wei-Wei Gao, Jie Kang, Gui-Xin Cai, Cheng-He Zhou.Discovery of benzimidazole quinolone hybrids as new cleaving agents towards drug-resistantP. aeruginosaDNA. ChemMedChem, 2018, 13, 1004–1017.(JCR 3区, IF = 3.124)

[18] Xian-Fu Fang, Di Li, Vijai Kumar Reddy Tangadanchu, Lavanya Gopala,Wei-Wei Gao, Cheng-He Zhou. Novel potentially antifungal hybrids of 5-flucytosine and fluconazole: Design, synthesis and bioactive evaluation. Bioorganic & Medicinal Chemistry Letters, 2017, 27, 4964–4969. (JCR 3区, IF = 2.572)

[19] Zhen-Zhen Li, Lavanya Gopala, Vijai Kumar Reddy Tangadanchu,Wei-Wei Gao, Cheng-He Zhou. Discovery of novel nitroimidazole enols asPseudomonas aeruginosaDNA cleavage agents. Bioorganic & Medicinal Chemistry, 2017, 25, 6511–6522. (JCR 3区, IF = 3.073)

[20] Dinesh Addla, Si-Qi Wen,Wei-Wei Gao, Swetha Kameswari Maddili, Ling Zhang, Cheng-He Zhou. Design, synthesis, biological evaluation of novel carbazole aminothiazoles as potential DNA-targeting anti-MRSA agents. MedChemComm, 2016, 7, 1988–1994. (JCR 3区, IF = 2.807)

2、参加交流会议论文

[1]Wei-Wei Gao, Yong-Hua Lu, Fang Xu, Guang-Xian Zhang, Feng-Xiu Zhang.Study of a novel phosphorus-containing flame retardant for cotton fabric.IOP Conf. Series: Materials Science and Engineering, 2015, 87, 012107 (EI收录).

[2]Wei-Wei Gao, Feng-Xiu Zhang,Cheng-He Zhou. Effect of imidazoliums on the activity and stability of enzymes.Abstracts for CCS & The 9th National Organic Chemistry Conference, July 28-31, 2015, Changchun, China, p991.

[3]Wei-Wei Gao, Nagarajan Sangaraiah, Rasheed Syed, Feng-Xiu Zhang,Cheng-He Zhou. Synthesis of the first phosphonate bis-tetrazoles as fluconazole analogs.Abstracts for CCS & The 12th National Synthetic Organic Chemistry Symposium, October 15-18, 2015, Guilin, China, p142.

[4]Wei-Wei Gao, Jeyakkumar Ponmani,Cheng-He Zhou. The effect of metal ions on supramolecular transportation of organophosphorus imidazole by human serum albumin.Abstracts for The 18th Macrocyclic Chemistry and 10th Symposium of Supramolecular Chemistry, August 25-28, 2016, Changsha, China, p223.Honored “Best Poster Award”.

[5]Wei-Wei Gao,Cheng-He Zhou, Feng-Xiu Zhang. Design and synthesis of phosphonates triazole derivatives prodrugs.Abstracts for CMCS 2015 & 5th CPA-RSC Symposium, August 23-26, 2015, Lanzhou, China.

[6]Wei-Wei Gao, Vijai Kumar Reddy Tangadanchu,Cheng-He Zhou. Aminothiazolyl tetrahydroprotoberberrubines as new potentially multi-targeting antibacterial agents.Abstracts for CMCS CPA-EFMC International Symposium Medicinal Chemistry, August 27-30, 2017, Beijing, China.

3、授权专利

[1]周成合,玛尼•杰克库玛(Ponmani Jeyakkumar),高巍伟,程宇,张国彪,坦咖丹初•维加库玛•瑞迪(Tangadanchu Vijai Kumar Reddy).烯酮键链的黄连素唑类衍生物制备方法和应用,中国专利,授权号: ZL 201611042916.9,授权公告日: 2018.08.14.

科研项目

[1] 2017.01–2020.12,国家自然科学基金,21672173,基于氨基噻唑超分子相互作用的抗菌药物设计及相关多靶向性研究,在研,主要参与人。

[2]2019.03-2024.03,青岛科技大学高层次人才引进启动经费,210-010029049,基于天然药物黄藤素类抗菌分子设计与多靶向研究,在研,项目负责人。

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