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高巍伟
发布时间:2020-05-13    作者:      审核人:    点击:[]

化工学院教师介绍:高巍伟

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个人简介

工作职位: 制药工程教研室 硕士生导师

办公地址: 青岛科技大学科技园北楼614

工作邮箱: gww501@qust.edu.cn; gww51@email.swu.edu.cn

20186月毕业于西南大学有机化学专业,获理学博士学位。20189-至今,在青岛科技大学化工学院从事科研与教学工作。主要研究方向为:生物有机药物合成、环境药物检测、纳米复合材料的合成与生物应用等领域。发表SCI学术论文20篇,以第一作者或唯一通讯作者在European Journal of Medicinal ChemistrySCIENCE CHINA ChemistryFuture Medicinal ChemistryBiochemical Engineering JournalCelluloseCarbohydrate PolymersElectroanalysisJournal of The Electrochemical SocietyMicrochemical Journal等国内外学术期刊发表SCI收录学术论文12篇,其中,ESI高被引论文1篇。申请国家发明专利2项,授权1项。

教学情况

研究生课程

高等有机波谱分析:32课时,硕士生,20/

本科生课程

药物波谱分析:32课时,本科生,125/年。

论文、专著与专利

1主要论文

[1] Wei-Wei Gao, Lavanya Gopala, Rammohan R. Yadav Bheemanaboina, Guo-Biao Zhang, Shuo Li, Cheng-He Zhou. Discovery of 2-aminothiazolyl berberine derivatives as novel effectively antibacterial agents toward clinical drug-resistant Gram-negative Acinetobacter baumanii. European Journal of Medicinal Chemistry, 2018, 146, 15–37. (ESI高被引)

[2] Wei-Wei Gao, Syed Rasheed, Vijai Kumar Reddy Tangadanchu, Yi Sun, Xin-Mei Peng, Yu Cheng, Feng-Xiu Zhang, Jian-Mei Lin, Cheng-He Zhou. Design, synthesis and biological evaluation of amino organophosphorus imidazoles as a new type of potential antimicrobial agents. SCIENCE CHINA Chemistry, 2017, 60, 769–785. (国内T)

[3] Wei-Wei Gao, Cheng-He Zhou. Antimicrobial 2-aminothiazolyl quinolones: what is their potential in the clinic? Future Medicinal Chemistry, 2017, 9, 1461–1464.

[4] Wei-Wei Gao, Feng-Xiu Zhang, Guang-Xian Zhang, Cheng-He Zhou. Key factors affecting the activity and stability of enzymes in ionic liquids and novel applications in biocatalysis. Biochemical Engineering Journal, 2015, 99, 67–84.

[5] Wei-Wei Gao, Guang-Xian Zhang, Feng-Xiu Zhang. Enhancement of flame retardancy of cotton fabrics by grafting a novel organic phosphorous-based flame retardant. Cellulose, 2015, 22, 2787–2796.

[6] Feng-Xiu Zhang (硕士导师), Wei-Wei Gao, Ya-Ling Jia, Yi Lu, Guang-Xian Zhang. A concise water-solvent synthesis of highly effective, durable, and eco-friendly flame-retardant coating on cotton fabrics. Carbohydrate Polymers, 2018, 199, 256–265.

[7] Ya-Mu Xia, Wen Zhang, Meng-Ying Li, Meng Xia, Li-Jia Zou, Wei-Wei Gao*. Effective electrochemical determination of chloramphenicol and florfenicol based on graphene/copper phthalocyanine nanocomposites modified glassy carbon electrode. Journal of The Electrochemical Society, 2019, 166, B654-B663.

[8] Ya-Mu Xia, Jia-Hong Zhang, Meng Xia, Yan Zhao, Shan-Peng Chu, Wei-Wei Gao*. Peony-like magnetic graphene oxide/Fe3O4/BiOI nanoflower as a novel photocatalyst for enhanced photocatalytic degradation of Rhodamine B and Methylene blue dyes. Journal of Materials Science Materials in Electronics, 2020, 31, 1996-2009.

[9] Ya-Mu Xia, Meng-Ying Li, Cheng-Long Chen, Meng Xia, Wen Zhang, Wei-Wei Gao*. Employing 3D-rGO-PANI based DNA biosensor as label-free and ultrasensitive “nano-detector” for breast cancer BRCA1 sensing. Electroanalysis, 2020, 32, 2045–2055.

[10] Ya-Mu Xia, Shan-Peng Chu, Zi-Yang Liao, Shu-Yu Sun, Xu Cheng, Wei-Wei Gao*. Z-scheme mechanism study of ternary BiPO4/reduced graphene oxide/protonated g-C3N4 photocatalyst with interfacial electric field mediating for the effective photocatalytic degradation of tetracycline. Journal of Materials Science Materials in Electronics, 2020, 31, 14886–14900.

[11] Shu-Zhen Yang, Zhi-Qiang Dong, Cheng-Cheng Yin, Hui-Juan Yue, Wei-Wei Gao*, Feng-Ke Yang*. Green synthesis of caffeine based on methylating reagent DMC and environmental friendly separating method. Journal of the Chinese Chemical Society, 2020, 67, 1715–1720.

[12] Ya-Mu Xia, Meng Xia, Yan Zhao, Meng-Yin Li, Xiang Ou, Wei-Wei Gao*. Photocatalytic electrochemical sensor based on three-dimensional graphene nanocomposites for the ultrasensitive detection of CYFRA21-1 gene. Microchemical Journal, 2021, DOI: 10.1016/j.microc.2021.106245.

[13] Ya-Mu Xia, Xiang Ou, Yan Zhao, Meng Xia, Dong Chen, Wei-Wei Gao*. Facile synthesis of reduced graphene oxide-octahedral Mn3O4 nanocomposites as a platform for the electrochemical determination of metronidazole and sulfamonomethoxine. Electroanalysis, 2021, DOI: 10.1002/elan.202100015.

[14] Han-Bo Liu, Wei-Wei Gao, Vijai Kumar Reddy Tangadanchu, Cheng-He Zhou, Rong-Xia Geng. Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation. European Journal of Medicinal Chemistry, 2018, 143, 66–84.

[15] Guo-Biao Zhang, Swetha Kameswari Maddili, Vijai Kumar Reddy Tangadanchu, Lavanya Gopala, Wei-Wei Gao, Gui-Xin Cai, Cheng-He Zhou. Discovery of natural berberine-derived nitroimidazoles as potentially multi-targeting agents against drug-resistant Escherichia coli. SCIENCE CHINA Chemistry, 2018, 61, 557–568.

[16] Yu Cheng, Srinivasa Rao Avula, Wei-Wei Gao, Dinesh Addla, Vijai Kumar Reddy Tangadanchu, Ling Zhang, Jian-Mei Lin, Cheng-He Zhou. Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells. European Journal of Medicinal Chemistry, 2016, 124, 935945.

[17] Jie Kang, Lavanya Gopala, Vijai Kumar Reddy Tangadanchu, Wei-Wei Gao, Cheng-He Zhou. Novel naphthalimide nitroimidazoles as multi-targeting antibacterial agents against resistant Acinetobacter baumannii. Future Medicinal Chemistry, 2018. 10, 711–724.

[18] Jie Kang, Vijai Kumar Reddy Tangadanchu, Lavanya Gopala, Wei-Wei Gao, Yu Cheng, Han-Bo Liu, Rong-Xia Geng, Shuo Li, Cheng-He Zhou. Novel potentially antibacterial naphthalimide-derived metronidazoles: Design, synthesis, biological evaluation and supramolecular interactions with DNA, human serum albumin and topoisomerase II. Chinese Chemical Letters, 2017, 28, 1369–1374.

[19] Ya-Nan Wang, Rammohan R. Yadav Bheemanaboina, Wei-Wei Gao, Jie Kang, Gui-Xin Cai, Cheng-He Zhou. Discovery of benzimidazole quinolone hybrids as new cleaving agents towards drug-resistant P. aeruginosa DNA. ChemMedChem, 2018, 13, 1004–1017.

[20] Xian-Fu Fang, Di Li, Vijai Kumar Reddy Tangadanchu, Lavanya Gopala, Wei-Wei Gao, Cheng-He Zhou. Novel potentially antifungal hybrids of 5-flucytosine and fluconazole: Design, synthesis and bioactive evaluation. Bioorganic & Medicinal Chemistry Letters, 2017, 27, 4964–4969.

[21] Zhen-Zhen Li, Lavanya Gopala, Vijai Kumar Reddy Tangadanchu, Wei-Wei Gao, Cheng-He Zhou. Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents. Bioorganic & Medicinal Chemistry, 2017, 25, 6511–6522.

[22] Dinesh Addla, Si-Qi Wen, Wei-Wei Gao, Swetha Kameswari Maddili, Ling Zhang, Cheng-He Zhou. Design, synthesis, biological evaluation of novel carbazole aminothiazoles as potential DNA-targeting anti-MRSA agents. MedChemComm, 2016, 7, 1988–1994.

2、参加交流会议论文

[1] Wei-Wei Gao, Yong-Hua Lu, Fang Xu, Guang-Xian Zhang, Feng-Xiu Zhang. Study of a novel phosphorus-containing flame retardant for cotton fabric. IOP Conf. Series: Materials Science and Engineering, 2015, 87, 012107 (EI收录).

[2] Wei-Wei Gao, Feng-Xiu Zhang, Cheng-He Zhou. Effect of imidazoliums on the activity and stability of enzymes. Abstracts for CCS & The 9th National Organic Chemistry Conference, July 28-31, 2015, Changchun, China, p991.

[3] Wei-Wei Gao, Nagarajan Sangaraiah, Rasheed Syed, Feng-Xiu Zhang, Cheng-He Zhou. Synthesis of the first phosphonate bis-tetrazoles as fluconazole analogs. Abstracts for CCS & The 12th National Synthetic Organic Chemistry Symposium, October 15-18, 2015, Guilin, China, p142.

[4] Wei-Wei Gao, Jeyakkumar Ponmani, Cheng-He Zhou. The effect of metal ions on supramolecular transportation of organophosphorus imidazole by human serum albumin. Abstracts for The 18th Macrocyclic Chemistry and 10th Symposium of Supramolecular Chemistry, August 25-28, 2016, Changsha, China, p223. Honored “Best Poster Award”.

[5] Wei-Wei Gao, Cheng-He Zhou, Feng-Xiu Zhang. Design and synthesis of phosphonates triazole derivatives prodrugs. Abstracts for CMCS 2015 & 5th CPA-RSC Symposium, August 23-26, 2015, Lanzhou, China.

[6] Wei-Wei Gao, Vijai Kumar Reddy Tangadanchu, Cheng-He Zhou. Aminothiazolyl tetrahydroprotoberberrubines as new potentially multi-targeting antibacterial agents. Abstracts for CMCS CPA-EFMC International Symposium Medicinal Chemistry, August 27-30, 2017, Beijing, China.

3、授权专利

[1] 周成合, 玛尼杰克库玛 (Ponmani Jeyakkumar), 高巍伟, 程宇, 张国彪, 坦咖丹初维加库玛瑞迪 (Tangadanchu Vijai Kumar Reddy). 烯酮键链的黄连素唑类衍生物制备方法和应用, 中国专利, 授权号: ZL 201611042916.9, 授权公告日: 2018.08.14.

科研项目

[1] 2017.01–2020.12,国家自然科学基金,21672173,基于氨基噻唑超分子相互作用的抗菌药物设计及相关多靶向性研究,结题,主要参与人。

[2] 2021.01–2023.12,山东省自然科学基金,ZR2020QB168,基于植物源黄藤抗菌分子设计与多靶向性作用机制研究,在研,项目负责人。

[3] 2019.032024.03,青岛科技大学高层次人才引进启动经费,210-010029049基于天然药物黄藤素类抗菌分子设计与多靶向研究,在研,项目负责人。

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